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Tuesday, June 23, 2020

Asymptomatic COVID-19 patients still get lung damage

A Scripps 
study suggests 
the COVID-19
infected people 
with no symptoms,
( asymptomatic ) 
may be getting
damaged lungs.

These studies 
are small, 
non-randomized, 
retrospective 
studies.

Conclusion:
The absence of 
COVID-19 symptoms 
for infected people 
may NOT imply 
an absence of harm. 

Results from China, 
Japan, and the US
show that half 
or more of the 
asymptomatic 
COVID-19 cases 
have lung damage.



(1)
A Small Chinese Study: 
  Asymptomatic cases 
had a slower immune 
response to COVID-19, 
which means 
they were shedding 
the virus over a 
longer period of time 
than the cases 
with symptoms.

A Scripps review 
found the rate of lung 
damage was 
about 50% of the
asymptomatic 
cases.

COVID-19 infection 
may be impacting 
lung function
that might not be 
immediately 
apparent.

People might 
not notice 
their lungs were 
under performing, 
because we have 
extra lung capacity 
for day to day living.

178 patients 
( median age 41 )
with PCR-confirmed 
SARS-CoV-2 infection 
in the Wanzhou District 
in China, included 
37 people without 
any symptoms. 

Lab tests show 
there was some
lung damage 
in just over half the 
asymptomatic group, 
and there was some
liver damage too.



(2)
Diamond Princess Cruise Ship:
A CT scan of asymptomatic 
people on the ship
 ( CT = Computed Tomography )
was conducted, and 54% 
of 76 asymptomatic
patients, appear to show 
significant subclinical 
lung abnormalities.



REFERENCES
Long QX, et al

“Clinical and immunological 
assessment of asymptomatic 
SARS-CoV-2 infections” 

Nat Med 2020; 
DOI: 10.1038/s41591-020-0965-6.
https://www.nature.com/articles/s41591-020-0965-6



Ran and Topal, (2020)